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Since 1986 MetaSystems has been designing and manufacturing systems for computerized automated microscopic imaging. From the very beginning, the close relationship to the end user has been an essential part of the MetaSystems philosophy. The following three decades have revealed that this was a successful strategy; from humble beginnings, MetaSystems has grown into a leading solution provider which still remains connected to its strong roots.

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Toxicology Studies with the Comet Assay and the in-vivo Micronucleus Assay

The genotoxic potential of azidothymidine [...], chosen as a model compound for nucleotide analogs, was comprehensively assessed in vivo for gene mutation, clastogenicity, and DNA breakage endpoints. [...] For the comet assay, liver and stomach were sampled. [...] Coded slides were analyzed by Metafer/Relosys4. A total of 150 comets per slide were measured. [...] For the micronucleus assay in bone marrow, the test methodology was in accordance with requirements of the OECD Guideline 474 [...]. A total of 4000 polychromatic erythrocytes (PCEs) per animal were evaluated for the occurrence of micronuclei and the relative proportion of PCE in relation to normochromatic erythrocytes (NCEs). Blinded slides were analyzed using the Metafer /Relosys 4. Statistical evaluation was performed for the frequency of micronucleated (MN)-PCE. [...] In the comet assay as well as the micronucleus test, AZT caused a considerable dose-dependent increase in DNA damage in all tissues evaluated and was highly cytotoxic to bone marrow and peripheral blood cells. These data are well in line with published results.

Cited From: Toxicol Sci (2013) Read more...
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New MetaSystems Office in Latin America

MetaSystems proudly announces the opening of our first subsidiary in the Southern hemisphere. The new office is located in Buenos Aires, Argentina and bears the name MetaSystems Latinoamérica SAS (MetaSystems LatAm). The foundation has been the response to the growing demand on technical knowledge and 'know how' experienced in the last years all over the Latin American territories. MetaSystems LatAm takes care for the organization of sales, support, and customer relation activities in all countries in Latin America. It will manage distributor companies and contacts in the region, and it will facilitate communication between end-users, distributors and headquarters in Germany.

New MetaSystems Office in Latin America
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