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Detection of circulating endothelial and tumor cells
Non-hematopoietic circulating rare cells (CRCs) mainly consist of circulating tumor cells (CTCs) and circulating endothelial cells (CECs). Clinical relevance of CECs in tumor angiogenesis1 and CTCs in tumor metastasis [...] have been substantially discussed elsewhere. [...] In the present report, we extended our previous prototyping study to significantly improve the unique strength of SE-iFISH, which was developed to combine in situ phenotypic identification of tumor biomarker and karyotypic characterization of chromosome ploidy in CRCs enriched from patient biofluids (blood, bone marrow, ascites, malignant pleural effusion, and cerebrospinal fluids, etc.) [...]. [...] Metafer-iFISH®, an automated CRC scanning and image analysis system, was recently co-developed by Carl Zeiss (Oberkochen, Germany), MetaSystems (Altlussheim, Germany) and Cytelligen (San Diego, CA, USA) [...]. High through-put X-Y-Z 3-dimensional slide scanning, image acquisition, processing, classification of CRC subtypes, and statistical analyses of each subcategory of the target cells could be fully automatically performed by Metafer-iFISH upon cell size, cell cluster, quantified chromosome ploidy, and immunofluorescence staining intensity of multi-tumor biomarkers expression displayed in diverse fluorescence channels, avoiding interference from human error or bias. [...] The novel SE-iFISH provides a unique strategy for expeditious and effective enrichment, in situ phenotypic as well as karyotypic co-detection of various non-hematopoietic CRCs in cancer patients or metastatic mouse model of patient derived xenograft (mPDX)33, which allows for classification of CTCs and CECs into diverse subtypes upon biomarker expression as well as chromosome ploidy, and each subtype of CRCs may correlate with distinct clinical outcome, such as tumor angiogenesis, cancer metastasis, relapse and therapeutic drug resistance [...].
Cited From: Nature Scientific Reports (2017)
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Workshop on Automated Cytogenetics in Mexico
Together with our partner Carl Zeiss de México S.A. de C.V., MetaSystems conducted a workshop addressing the automation of lab environments in cytogenetics, hematology, pathology, biodosimetry and other fields of work.
Workshop on Automated Genetic Toxicology at KIT, Daejeong, Korea
The Korea Institute of Toxicology (KIT) is a government-funded research institute to evaluate the safety of medicine, bio-related products and chemicals such as agricultural pesticides, food additives and cosmetics, environmental toxicity and ecotoxicity. As a leading provider of non-clinical toxicology studies, KIT serves as a core infrastructure in the biotechnology industry. In May 2019, Dr. Seong-Hoon Park from KIT organized the first KIT Workshop for Automated Genetic Toxicology Testing. On this event, which was kindly supported by Mirax Corporation, local and overseas speakers summarized current proceedings in the automation of genetic toxicology test analysis.
