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Aneuploid CTC and CEC

Circulating tumor cells (CTCs) are cancer cells shed from primary or metastatic solid tumors into peripheral blood, whereas circulating endothelial cells (CECs) are derived from endothelial cells (ECs) of blood vessels into circulation. Clinical relevance of CTCs in tumor metastasis and prognosis [...], CECs in tumor angiogenesis [...], and CEC clusters in carcinoma [...] have been substantially discussed elsewhere. [...] Detection of circulating rare cells (CRCs), including both CTCs and CECs, is the most representative of liquid biopsy due to its unique availability of frequent and non-invasive detecting tumor cells in carcinoma patients. [...] Somatic aneuploidy is the most common characteristic of human carcinomas [...]. Approximately 90% of solid tumors and 75% of hematological carcinomas exhibit aneuploidy [...]. In particular, aneuploid chromosome 8 (Chr 8) was observed in neoplasm cells of several solid tumors, including lung, gastric, pancreatic, colon, bladder, esophageal, and hepatocellular carcinomas, etc. [...]. [...] The established SE-iFISH strategy, facilitated by the newly developed Metafer-iFISH [...] automated CRC image scanning and analysis system [...], provides a unique comprehensive platform to effectively detect, phenotypically and karyotypically characterize CRCs with cytogenetic abnormalities of chromosome aneuploidy or gene rearrangements (such as ALK gene) in situ, in both patients and PDX tumor animal models.

Cited From: Diagnostics (Basel, Switzerland) (2018) Read more...
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