Upcoming Event in Netherlands from May 23 to May 26, 2022
In 2022, the 14th ICAW will be hosted by the Department of Pharmacology & Toxicology of Maastricht University and financially supported by the Limburg University Fund/SWOL.
Innovative Solutions for Automated Imaging
MetaSystems has been developing and producing system software for automated microscopy since 1986. Today, users in more than 100 countries rely on the laboratory solutions by MetaSystems.
In addition to generating the highest quality images, our modern approaches include an advanced workflow management that grows with your requirements and the use of artificial intelligence for image assessment.
To learn more about our innovative lab solutions, we encourage you to begin on the applications pages.
You would like to discover what others are accomplishing with their MetaSystems products? Read through the list of peer-reviewed publications from our customers!
If you do not find what you are looking for, please do not hesitate to contact the MetaSystems partner in your region.
Toxicology Studies with the Comet Assay and the in-vivo Micronucleus Assay
The genotoxic potential of azidothymidine [...], chosen as a model compound for nucleotide analogs, was comprehensively assessed in vivo for gene mutation, clastogenicity, and DNA breakage endpoints. [...] For the comet assay, liver and stomach were sampled. [...] Coded slides were analyzed by Metafer/Relosys4. A total of 150 comets per slide were measured. [...] For the micronucleus assay in bone marrow, the test methodology was in accordance with requirements of the OECD Guideline 474 [...]. A total of 4000 polychromatic erythrocytes (PCEs) per animal were evaluated for the occurrence of micronuclei and the relative proportion of PCE in relation to normochromatic erythrocytes (NCEs). Blinded slides were analyzed using the Metafer /Relosys 4. Statistical evaluation was performed for the frequency of micronucleated (MN)-PCE. [...] In the comet assay as well as the micronucleus test, AZT caused a considerable dose-dependent increase in DNA damage in all tissues evaluated and was highly cytotoxic to bone marrow and peripheral blood cells. These data are well in line with published results.
Cited From: Toxicol Sci (2013)
Read more...
All Publications
Related Products/Solutions
Are You Looking for Probes?
MetaSystems Probes now has its own website. If you are looking for MetaSystems XCyting DNA Probes, please visit the MetaSystems Probes website.
Next Event
Latest News
Update on MetaSystems and the In Vitro Diagnostics Regulation (IVDR)
On May 26, 2022, In Vitro Diagnostics Regulation (IVDR; Regulation (EU) 2017|746) becomes mandatory and replaces the In Vitro Diagnostics Directive (IVDD; Directive 98/79/EC). However, a progressive roll-out of the new IVDR was decided for existing products.
Deliveries to Russia
We are following the current events in Ukraine with great concern. We have therefore decided to suspend our deliveries to Russia until further notice.
