Nearly 4,200 scientists– a record number –who submitted an abstract for ASM Microbe 2019 can’t be wrong.
Innovative Solutions for Automated Imaging
Since 1986 MetaSystems has been designing and manufacturing systems for computerized automated microscopic imaging. From the very beginning, the close relationship to the end user has been an essential part of the MetaSystems philosophy. The following three decades have revealed that this was a successful strategy; from humble beginnings, MetaSystems has grown into a leading solution provider which still remains connected to its strong roots.
MetaSystems’ latest innovation, Neon, is a dynamic, modern imaging platform which reliably manages cases, images, and results from single workstation environments to large multi-user, multi-site installations. The Neon imaging platform ensures that all relevant information is accessible whenever needed.
Maybe you can find a solution to your imaging automation problem here on this web site. We recommend starting your journey on the application pages, if you are not familiar with our product portfolio. In case you are, it may be easier to go directly to the page for the product you actually look for. Should you feel lost, please feel free to contact us or the MetaSystems partner in your country.
We believe in communication being the first step towards innovative solutions!
Automated Interpretation of Blood Culture Gram Stains
Microscopic interpretation of stained smears is one of the most operator-dependent and time-intensive activities in the clinical microbiology laboratory. [...] With consolidation of hospital systems, increasing workloads, and the potential unavailability of highly trained microbiologists on site [...], automated image collection paired with computational interpretation of Gram stains to augment and complement manual testing would provide benefit. [...] Practically, automated Gram stain interpretation requires both automated slide imaging and automated image analysis. [...] A total of 468 deidentified Gram-stained slides from positive blood cultures were collected from the clinical microbiology laboratory at Beth Israel Deaconess Medical Center [...]. All slides were imaged without coverslips using a Metafer Slide Scanning and Imaging platform [...] with a 140-slide-capacity automated slide loader equipped with a 40 magnification Plan-Neofluar objective [...]. Slides were selected based on the presence of any of the three most common morphotypes observed in bloodstream infection: Gram-positive cocci in clusters, Gram-positive cocci in pairs and chains, and Gram-negative rods. [...] We performed image acquisition on a Metafer [...] based on a robust Gram stain-compatible autofocus system, ability to sample multiple distributed positions on a slide to account for variations in specimen distribution, and automated slide loading capability to enable high-throughput slide scanning. Clinically, Gram stains are read under oil immersion. However, semicontinuous addition of oil during automated microscopy was undesirable. In preliminary experiments performed with slides that were not coverslipped (data not shown), we determined that the 40 dry objective provided sufficient resolution for machine learning applications based on our prior experience [...]. Therefore, we selected use of the 40x air objective for image acquisition, thus avoiding the requirement for oil immersion and allowing us to capture a larger field of view in each image. [...] Here, we demonstrated that the Metafer Slide Scanning and Imaging platform provides a robust automated image acquisition system, capable of providing sufficient resolution for Gram stain analysis using a 40 dry objective. [...] Overall, we found that our trained model performed well on whole-slide image classification. Where cells were detected, we achieved an overall classification accuracy of 92.5% and a specificity of 93% for all classification labels with no human intervention. [...]
Are You Looking for Probes?
MetaSystems Probes now has its own website. If you are looking for MetaSystems XCyting DNA Probes, please visit the MetaSystems Probes website.
Workshop on Automated Cytogenetics in Mexico
Together with our partner Carl Zeiss de México S.A. de C.V., MetaSystems conducted a workshop addressing the automation of lab environments in cytogenetics, hematology, pathology, biodosimetry and other fields of work.
Workshop on Automated Genetic Toxicology at KIT, Daejeong, Korea
The Korea Institute of Toxicology (KIT) is a government-funded research institute to evaluate the safety of medicine, bio-related products and chemicals such as agricultural pesticides, food additives and cosmetics, environmental toxicity and ecotoxicity. As a leading provider of non-clinical toxicology studies, KIT serves as a core infrastructure in the biotechnology industry. In May 2019, Dr. Seong-Hoon Park from KIT organized the first KIT Workshop for Automated Genetic Toxicology Testing. On this event, which was kindly supported by Mirax Corporation, local and overseas speakers summarized current proceedings in the automation of genetic toxicology test analysis.