The 34th meeting of the German, Austrian, and Swiss Society of Human Genetics (GfH) will be held in Kassel. The scientific focus of the meeting is on the therapy of rare diseases.
Innovative Solutions for Automated Imaging
MetaSystems has been developing and producing system software for automated microscopy since 1986. Today, users in more than 100 countries rely on the laboratory solutions by MetaSystems.
In addition to generating the highest quality images, our modern approaches include an advanced workflow management that grows with your requirements and the use of artificial intelligence for image assessment.
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Toxicology Studies with the Comet Assay and the in-vivo Micronucleus Assay
The genotoxic potential of azidothymidine [...], chosen as a model compound for nucleotide analogs, was comprehensively assessed in vivo for gene mutation, clastogenicity, and DNA breakage endpoints. [...] For the comet assay, liver and stomach were sampled. [...] Coded slides were analyzed by Metafer/Relosys4. A total of 150 comets per slide were measured. [...] For the micronucleus assay in bone marrow, the test methodology was in accordance with requirements of the OECD Guideline 474 [...]. A total of 4000 polychromatic erythrocytes (PCEs) per animal were evaluated for the occurrence of micronuclei and the relative proportion of PCE in relation to normochromatic erythrocytes (NCEs). Blinded slides were analyzed using the Metafer /Relosys 4. Statistical evaluation was performed for the frequency of micronucleated (MN)-PCE. [...] In the comet assay as well as the micronucleus test, AZT caused a considerable dose-dependent increase in DNA damage in all tissues evaluated and was highly cytotoxic to bone marrow and peripheral blood cells. These data are well in line with published results.
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