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RENEB Intercomparison Exercises Analyzing Micronuclei

Radiological emergencies in which a large number of victims are involved can occur as the result of different events such as radiation accidents, terrorist attacks with dirty bombs or other kinds of exposure to radioactive sources. In the event of large radiological accidents, an initial triage aimed at classifying victims according to the degree of exposure is indicated to guide appropriate clinical responses. [...] The cytokinesis-block (CB) micronucleus (MN) assay, originally developed by Fenech and Morley in 1985, is a valuable biodosimetric tool for quantifying radiation-induced chromosomal damage for population triage thanks to the simplicity of MN scoring and the availability of automated MN analysis using microscopy-based [...] methods. [...] Five laboratories performed both automated and semi-automated MN scoring using the Metafer platform (Metasystems, Altlussheim, Germany). [...] The lowest level of inhomogeneity was obtained for the automated scoring group where a more standardized approach was applied. [...] The results of the two micronucleus intercomparison exercises performed by the RENEB network, demonstrate that the cytokinesis-block MN assay is a useful triage tool for large-scale
radiation emergencies.

Cited From: International journal of radiation biology (2017) Read more...
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