About 100 guests from 36 countries met on the XVIII. MetaSystems Distributor Meeting (DM) in November to exchange experiences and to get to know new trends and developments at MetaSystems.
MetaSystems DM2019 Largest in History
Metafer
Scanning and Imaging Platform
Metafer conveniently automates a wide area of image analysis applications in microscopy for life sciences.
Due to Metafer's modularity and its flexible architecture it is applicable to a large variety of applications. More than 1,500 Metafer scanning platforms are worldwide in use as metaphase finders, FISH signal counters, toxicology workstations, sample digitizers, and more.
Metafer adds slide scanning functionality to a Neon system. It scans specimen of various sizes, uses many different contrasting methods and magnifications, and finds many different target objects. Due to Metafer's modularity and its flexible architecture, it is applicable to numerous applications, including cytogenetic diagnostics, hematology, pathology, toxicology, forensic sciences, and many more.
Of course, automated imaging saves time. But even more important is reproducibility, achieved by applying clearly defined standards to any analysis - slide by slide, experiment by experiment, and patient by patient. This way Metafer adds an unbiased degree of quality to your results. Complex analysis systems tend to be cumbersome and difficult to understand. Metafer is much different: unlimited access to all data, convenient display of results, and full control of all evaluation parameters guarantee that results are generated exactly the way you want. Slide scanning becomes extremely easy with Metafer.
Each microscopic sample is different: automation of analysis therefore demands flexibility. Metafer’s unique concept provides a powerful solution: user-trainable classifiers precisely define the analysis standards, and with the selection of the appropriate classifier the system is quickly switched to the next assay.
Metafer grows with demand. Software and hardware are modular, and with higher workloads the level of automation can be increased; optional features such as the SlideFeeder x80, the automated Bar Code Reader, and the automated Immersion Oil Dispenser are easily added upon demand.
Metafer is a highly flexible system with many options, and every application has certain hardware and software requirements. A number of different software modules and hardware options are available. Please contact MetaSystems to receive a detailed recommended system configuration for your applications. In general, Metafer comes with 1 of 4 different camera models and with a motorized stage. A full Metafer system requires a motorized microscope. MetaSystems typically delivers the microscope with the system, but Metafer can also integrate with existing, compatible microscopes.
| Camera Model | Hardware Included | Microscope Required | |
| Metafer4 Complete Metafer System (Monochrome Version) |
MetaSystems CoolCube 1m 1360 x 1024 pixels; 6.45 μm x 6.45 μm 2/3" CCD, monochrome |
PC for Scanning Systems Computer Peripherals Motorized Stage |
Carl Zeiss AxioImager.Z2 (ScopeLED LED lightsource for brightfield recommended) |
| Metafer4 Complete Metafer System (Color Version) |
MetaSystems CoolCube 1c 1360 x 1024 pixels; 6.45 μm x 6.45 μm 2/3" CCD, color |
PC for Scanning Systems Computer Peripherals Motorized Stage |
Carl Zeiss AxioImager.Z2 (Not recommended for fluorescence imaging) |
| Metafer5 Complete Metafer System (Monochrome Version) |
MetaSystems CoolCube 4m 4096 x 3000 pixels; 3.45 μm x 3.45 μm 1.1" CCD, monochrome |
PC for Scanning Systems Computer Peripherals Motorized Stage |
Carl Zeiss AxioImager.Z2 (ScopeLED LED lightsource for brightfield recommended) |
| Metafer5 Complete Metafer System (Color Version) |
MetaSystems CoolCube 4c 4096 x 3000 pixels; 3.45 μm x 3.45 μm 1.1" CCD, color |
PC for Scanning Systems Computer Peripherals Motorized Stage |
Carl Zeiss AxioImager.Z2 (Not recommended for fluorescence imaging) |
| Metafer Review Station (System for remote reviewing of Metafer data) |
None | PC for Scanning Systems Computer Peripherals |
No (Requires network connection to a full Metafer system) |
| Metafer Analysis Station (System for remote reviewing of Metafer data and for virtual scanning) |
None | PC for Scanning Systems Computer Peripherals |
No (Requires network connection to a full Metafer system) |
| Relocation System ReloSys4 (System for motorized remote relocation of Metafer objects; standard resolution version) |
Optional | PC for Scanning Systems Computer Peripherals Motorized Stage |
Yes (Any motorized or manual microscope with C-mount) |
| Relocation System ReloSys5 (System for motorized remote relocation of Metafer objects; high resolution version) |
Optional | PC for Scanning Systems Computer Peripherals Motorized Stage |
Yes (Any motorized or manual microscope with C-mount) |
The list above is not exhaustive, and technical data may change. Please contact your MetaSystems representative for further explanations and details.
For special applications, a variety of software upgrades are available. Software upgrades require a functional Metafer system and a defined main module, which provides the basic tools required for the scan.
- Metaphase Search Reloaded, (5.2MB)
With more than 30 years of innovation in digital imaging analysis and automation, MetaSystems is proud to announce the next generation of Metaphase detection and analysis. Our complete AI powered workflow facilitates the entire tedious process of finding metaphases straight to completed karyograms for review. Metaphase scanning and image quality has been made even faster with our Ultra High-Resolution CoolCube 4 camera.
Also available in: - MetaSystems RNA FISH, (5.4MB)
MetaSystems is proud to present a high-performance solution to detecting SARS-CoV-2 RNA in cell and tissue samples, in partnership with PixelBiotech GmbH. Our solution provides you with a unique, precise, and comprehensive combination of RNA FISH (fluorescence in situ hybridization) probes and automated analysis equipment, allowing for the detection and quantification of the virus in samples.
- Metafer in Genetox, (2.9MB)
In combination with our CoolCube digital camera and state-of-the- art analysis software, Metafer - our fully automated slide scanning system - is the perfect solution for pharmaceutical toxicology laboratories and affiliated Contract Research Organizations (CROs).
- White Blood Cells Classification with DNN, (5.3MB)
White blood cells (WBCs) differential count is a widely performed hematological test for blood cancers diagnostic, inflammation and infection diseases detection. MetaSystems has developed a new algorithm based on a Deep Neural Network (DNN), and trained with thousands of pre-classified data, for an AI-assisted classification of WBCs.
Also available in: - AI Based In Vitro MN Detection, (3.8MB)
The analysis and quantification of micronuclei in vitro is a widely performed test for fast detection of DNA damage in cells exposed to ionizing radiation or genotoxic chemical agents. MetaSystems has developed a new Deep Neural Network (DNN) algorithm, trained with thousands of pre-classified data, which brings the advantages of Artificial Intelligence to the detection of MN cells on Giemsa-stained slides.
- CoolCube 1 CCD Camera, (1.4MB)
MetaSystems introduces CoolCube 1, a digital high resolution progressive scan CCD camera combining superior technical features
with an attractive price. CoolCube 1 is available as a monochrome version (CoolCube 1m) or as a Bayer-mask color version (CoolCube
1c). - Metafer, (3.9MB)
Metafer, MetaSystems' slide scanning platform, offers a unique combination of selected scanning hardware and outstanding imaging software, resulting in the most versatile and robust system available for microscope imaging automation.
- Neon, (3.4MB)
Neon, a tool for flexible and consistent image and case data management, represents the backbone of MetaSystems workstations. Neon was designed to collect data from different sources and integrate them into an efficient and well structured workflow. Neon reliably manages cases, images, and results of Metafer systems, individual Ikaros and Isis workstations, as well as large multiuser installations. It guarantees that all relevant information is visible whenever and wherever it is needed. Neon's powerful and flexible workflow settings integrates seamlessly with existing routines and can be applied to the complete range of MetaSystems imaging applications.
- CoolCube 4 and CoolCube 4 TEC CMOS Cameras, (1.4MB)
With the new camera model CoolCube 4, MetaSystems introduces the first ultra-high resolution camera supported by the Metafer slide scanning platform. Using a 1.1" CMOS chip with a pixel size of only 3.45 μm x 3.45 μm, all CoolCube 4 cameras acquire images with the size of 4,096 x 3,000 pixels.
- Poster: Combining a Slide Scanning Platform and Deep Learning Analysis Methods, (315.2kB)
Deep learning techniques can potentially support interpretation of digital Gram images. To match the growing demand for workload reduction and efficiency increase in the review process of Gram stained slides we have integrated deep learning-based object classification using convolutional neural networks (CNN) with our automated scanning platform Metafer to create a unique Gram slide screening environment.
Second MetaSystems User Day in Altlussheim, Germany
Neon, the outstanding MetaSystems case and image management system, offers many tools and helpful gadgets to streamline routine workflows, for example in cytogenetics labs. The second MetaSystems User Day, addressed to MetaSystems clients from Germany, Austria, and Switzerland, provided in different workshops knowledge helping to unleash the full power of the system.
OOO MetaSystems Russia on the International Scientific Congress 'Genetics of XXI Century'
The Congress 'Genetics of XXI Century' in Moscow, Russia (May 2019) has been one of the most important events for the professional international community of geneticists. Our partner company in Russia OOO MetaSystems considered it a good occasion to present the new camera CoolCube 4 connected to a state-of-the-art Neon system to the public.
