USCAP’s Annual Meeting at National Harbor, Maryland, close to the Capitol, is the magnet for global pathologists to come together to think out loud about what’s new, exciting and relevant in translational research and anatomic/molecular diagnostics. It’s the forum for intellectual stimulation, information exchange, and social interaction.
自 1986 年 MetaSystems 创立，本公司一直以设计生产和发展全自动显微镜成像系统为目标。MetaSystems 一贯以紧密的客户关系为重要的经营理念，在过去三十年本公司的成功全有赖于此。全赖于客户的支持，MetaSystems 一点一滴的成长，现已发展成为一个全球领先的全自动显微镜成像系统及其解决方案的供应商。
MetaSystems 全新的充满活力的现代化成像平台 Neon，可以让你轻松的管理从单一工作站到多用户、多工作站工作环境的病例、图像和结果。同时 Neon 的用户可以随时获取所有相关信息。
Automated Interpretation of Blood Culture Gram Stains
Microscopic interpretation of stained smears is one of the most operator-dependent and time-intensive activities in the clinical microbiology laboratory. [...] With consolidation of hospital systems, increasing workloads, and the potential unavailability of highly trained microbiologists on site [...], automated image collection paired with computational interpretation of Gram stains to augment and complement manual testing would provide benefit. [...] Practically, automated Gram stain interpretation requires both automated slide imaging and automated image analysis. [...] A total of 468 deidentified Gram-stained slides from positive blood cultures were collected from the clinical microbiology laboratory at Beth Israel Deaconess Medical Center [...]. All slides were imaged without coverslips using a Metafer Slide Scanning and Imaging platform [...] with a 140-slide-capacity automated slide loader equipped with a 40 magnification Plan-Neofluar objective [...]. Slides were selected based on the presence of any of the three most common morphotypes observed in bloodstream infection: Gram-positive cocci in clusters, Gram-positive cocci in pairs and chains, and Gram-negative rods. [...] We performed image acquisition on a Metafer [...] based on a robust Gram stain-compatible autofocus system, ability to sample multiple distributed positions on a slide to account for variations in specimen distribution, and automated slide loading capability to enable high-throughput slide scanning. Clinically, Gram stains are read under oil immersion. However, semicontinuous addition of oil during automated microscopy was undesirable. In preliminary experiments performed with slides that were not coverslipped (data not shown), we determined that the 40 dry objective provided sufficient resolution for machine learning applications based on our prior experience [...]. Therefore, we selected use of the 40x air objective for image acquisition, thus avoiding the requirement for oil immersion and allowing us to capture a larger field of view in each image. [...] Here, we demonstrated that the Metafer Slide Scanning and Imaging platform provides a robust automated image acquisition system, capable of providing sufficient resolution for Gram stain analysis using a 40 dry objective. [...] Overall, we found that our trained model performed well on whole-slide image classification. Where cells were detected, we achieved an overall classification accuracy of 92.5% and a specificity of 93% for all classification labels with no human intervention. [...]
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Meeting of the German Society of Human Genetics (gfh) in Weimar, Germany
The meeting of the German Society of Human Genetics (gfh) was held in Weimar, Germany this week and of course the attendees had the opportunity to visit the joined booth of MetaSystems and MetaSystems Probes. Main topics of the exhibition have been the latest advancements of the Neon case and imaging platform and RapidHyb, the revolutionary fast hybridization times of MetaSystems Probes' FISH probes.
Workshop on Genomic Instability
An "International Workshop on Genomic Instability: Basic and Applied Aspects" was jointly organized by Environmental Mutagen Society of India (EMSI) and School of Bio-sciences and Technology, Vellore Institute of Technology under the guidance of Prof. Wilner Martinez-Lopez (Biological Research Institute “Cemente Estable”-Uruguay, IIBCE) and Prof. Radha Saraswathy (School of Bio-sciences and Technology, VIT).