The ERRS meeting series belongs to a tradition of European conferences on radiation research initiated already in 1953. This year’s meeting is jointly organized by the Swedish Radiobiological Society and Lund University. Due to the Covid-19 pandemic, this event will be organized as a virtual conference.
自 1986 年 MetaSystems 创立，本公司一直以设计生产和发展全自动显微镜成像系统为目标。MetaSystems 一贯以紧密的客户关系为重要的经营理念，在过去三十年本公司的成功全有赖于此。全赖于客户的支持，MetaSystems 一点一滴的成长，现已发展成为一个全球领先的全自动显微镜成像系统及其解决方案的供应商。
Automated Interpretation of Blood Culture Gram Stains
Microscopic interpretation of stained smears is one of the most operator-dependent and time-intensive activities in the clinical microbiology laboratory. [...] With consolidation of hospital systems, increasing workloads, and the potential unavailability of highly trained microbiologists on site [...], automated image collection paired with computational interpretation of Gram stains to augment and complement manual testing would provide benefit. [...] Practically, automated Gram stain interpretation requires both automated slide imaging and automated image analysis. [...] A total of 468 deidentified Gram-stained slides from positive blood cultures were collected from the clinical microbiology laboratory at Beth Israel Deaconess Medical Center [...]. All slides were imaged without coverslips using a Metafer Slide Scanning and Imaging platform [...] with a 140-slide-capacity automated slide loader equipped with a 40 magnification Plan-Neofluar objective [...]. Slides were selected based on the presence of any of the three most common morphotypes observed in bloodstream infection: Gram-positive cocci in clusters, Gram-positive cocci in pairs and chains, and Gram-negative rods. [...] We performed image acquisition on a Metafer [...] based on a robust Gram stain-compatible autofocus system, ability to sample multiple distributed positions on a slide to account for variations in specimen distribution, and automated slide loading capability to enable high-throughput slide scanning. Clinically, Gram stains are read under oil immersion. However, semicontinuous addition of oil during automated microscopy was undesirable. In preliminary experiments performed with slides that were not coverslipped (data not shown), we determined that the 40 dry objective provided sufficient resolution for machine learning applications based on our prior experience [...]. Therefore, we selected use of the 40x air objective for image acquisition, thus avoiding the requirement for oil immersion and allowing us to capture a larger field of view in each image. [...] Here, we demonstrated that the Metafer Slide Scanning and Imaging platform provides a robust automated image acquisition system, capable of providing sufficient resolution for Gram stain analysis using a 40 dry objective. [...] Overall, we found that our trained model performed well on whole-slide image classification. Where cells were detected, we achieved an overall classification accuracy of 92.5% and a specificity of 93% for all classification labels with no human intervention. [...]
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Website also available in Brazilian Portuguese
MetaSystems is pleased to announce that our website is also now available in Brazilian Portuguese. With this change, our customers and all interested parties from one of our largest markets in Latin America will be able to read information in their local language.
Against the background of the worldwide appearance of the Corona virus (Sars CoV-2), the most important task for everyone at present is to contribute to slowing down its speed of propagation by adapting their behavior. Nevertheless, we are striving to maintain our services as far as possible and provide our customers and partners with the usual good service.