Innovative Solutions for Automated Imaging

MetaSystems has been developing and producing system software for automated microscopy since 1986. Today, users in more than 103 countries rely on the laboratory solutions by MetaSystems.

In addition to generating the highest quality images, our modern approaches include an advanced workflow management that grows with your requirements.

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Visualization of Angiogenesis During Cancer Development

Vascular endothelial growth factor receptor 2 (VEGFR2) is a crucial mediator of tumour angiogenesis. High expression levels of the receptor have been correlated to poor prognosis in cancer patients. The aim of this study was to investigate the pharmacokinetics and angiogenesis imaging abilities of the VEGFR2-targeting positron emission tomography (PET) tracer (R)-[11C]PAQ. [...] Whole slides were captured using a 10x [...] primary objective on a VSlide slide scanning microscope [...]. Individual field-of-view images were stitched to produce images of entire lung sections with microscopic resolution. Images were analysed using the (VSViewer) software [...]. The results indicate that (R)-[11C]PAQ is a promising imaging biomarker for visualization of angiogenesis, based on VEGFR2 expression, in primary tumours and during metastasis development.

Cited From: EJNMMI Res (2014) Read more...
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