The congress will take place from 21 to 24 September 2020 in Via Festa del Perdono at the ancient "Spedale di Poveri", built by Francesco Sforza and Bianca Maria Visconti from 1456 on a project by Antonio Averlino, known as Filarete.
自 1986 年 MetaSystems 创立，本公司一直以设计生产和发展全自动显微镜成像系统为目标。MetaSystems 一贯以紧密的客户关系为重要的经营理念，在过去三十年本公司的成功全有赖于此。全赖于客户的支持，MetaSystems 一点一滴的成长，现已发展成为一个全球领先的全自动显微镜成像系统及其解决方案的供应商。Your cookie settings prevent this video from being displayed.
Automated Interpretation of Blood Culture Gram Stains
Microscopic interpretation of stained smears is one of the most operator-dependent and time-intensive activities in the clinical microbiology laboratory. [...] With consolidation of hospital systems, increasing workloads, and the potential unavailability of highly trained microbiologists on site [...], automated image collection paired with computational interpretation of Gram stains to augment and complement manual testing would provide benefit. [...] Practically, automated Gram stain interpretation requires both automated slide imaging and automated image analysis. [...] A total of 468 deidentified Gram-stained slides from positive blood cultures were collected from the clinical microbiology laboratory at Beth Israel Deaconess Medical Center [...]. All slides were imaged without coverslips using a Metafer Slide Scanning and Imaging platform [...] with a 140-slide-capacity automated slide loader equipped with a 40 magnification Plan-Neofluar objective [...]. Slides were selected based on the presence of any of the three most common morphotypes observed in bloodstream infection: Gram-positive cocci in clusters, Gram-positive cocci in pairs and chains, and Gram-negative rods. [...] We performed image acquisition on a Metafer [...] based on a robust Gram stain-compatible autofocus system, ability to sample multiple distributed positions on a slide to account for variations in specimen distribution, and automated slide loading capability to enable high-throughput slide scanning. Clinically, Gram stains are read under oil immersion. However, semicontinuous addition of oil during automated microscopy was undesirable. In preliminary experiments performed with slides that were not coverslipped (data not shown), we determined that the 40 dry objective provided sufficient resolution for machine learning applications based on our prior experience [...]. Therefore, we selected use of the 40x air objective for image acquisition, thus avoiding the requirement for oil immersion and allowing us to capture a larger field of view in each image. [...] Here, we demonstrated that the Metafer Slide Scanning and Imaging platform provides a robust automated image acquisition system, capable of providing sufficient resolution for Gram stain analysis using a 40 dry objective. [...] Overall, we found that our trained model performed well on whole-slide image classification. Where cells were detected, we achieved an overall classification accuracy of 92.5% and a specificity of 93% for all classification labels with no human intervention. [...]
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Newly discovered security leak Ripple20 and MetaSystems devices
Lately it was discovered that many networked devices are vulnerable to remote attacks through 19 vulnerabilities. The flaws, collectively known as Ripple20, affect the TCP/IP stack. Unfortunately, also PC hardware used in combination with MetaSystems devices may be affected, and problems may arise if the network settings are not configured correctly or the workstation is connected directly to the internet. We therefore encourage our customers to update their system(s) to the latest firmware versions provided by the manufacturer.
Development of High Precision SARS-COV-2 (RNA) FISH Probes
The outbreak of the SARS-CoV-2 virus has led to global efforts to understand the mechanisms of the virus-induced Covid-19 disease and to seek to find effective countermeasures. In this context, our daughter company MetaSystems Italy joined forces with RNA-FISH specialist PixelBiotech for development of highly sensitive and precise SARS-Covid-2 probes.
Download the leaflet with details about the new technology here.