Development of High Precision SARS-COV-2 (RNA) FISH Probes

Jul 3, 2020

The outbreak of the SARS-CoV-2 virus has led to global efforts to understand the mechanisms of the virus-induced Covid-19 disease and to seek to find effective countermeasures.

In this context, our daughter company MetaSystems Italy joined forces with RNA-FISH specialist PixelBiotech for development of highly sensitive and precise SARS-Covid-2 probes. First result is the PixelBiotech SARS-COV-2 RNA FISH probe (RUO), targeting the most preserved sequence of the SARS-COV-2 spike gene and the ORF 1 (open reading frame 1) gene, located next to the spike gene. This probe – in combination with the MetaSystems Metafer1 slide scanning platform – is now being used in several Italian labs for detection and localization of the virus in cells and tissues and – not possible with any other method - for quantification of the virus. In addition to the SARS-COV-2 probe an ACE2 probe as well as various inflammation probes are available. Since results are very promising, first publications are to be expected very soon: we will keep our readers updated.

For more information please send a mail to [email protected].


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1 MetaSystems products are used in many countries worldwide. Depending on the regulations of the respective country or region, some products may not be used for clinical diagnostic use. In Europe MetaSystems products are CE labelled in-vitro diagnostics (IVD) devices. In the USA all MetaSystems products except the Ikaros karyotyping systems are intended to be used for research or inspection only.