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Ikaros

In Vitro Diagnostic Medical Device

Discover Scalable and Innovative Solutions for Karyotyping and Fluorescence Imaging

Ikaros is intended to be used for karyotyping with real-time microscope images from cultured and stained cell specimens in their metaphase. By transferring images of chromosome spreads from the microscope to a computer the labor-intensive manual processing of photographs is eliminated. Karyotypes are assembled by the operator with the support of image processing software. The results are documented in hardcopy and archived for later review.

The color fluorescence mode allows fast and easy acquisition, processing, archiving, and documentation of microscopic fluorescent images. All the steps from image acquisition to color printouts can be performed in just a few minutes. Images can easily be exported directly to other graphics and presentation software, which adds flexibility and convenience.

Images

Highlights

Karyotyping

  • Accommodate a diverse array of banding techniques currently in use.
  • Utilize various specimens for banding analysis, including amniotic fluid, peripheral blood, chorionic villus, bone marrow, and tissue, without limitations based on specific diseases.
  • Incorporate numerous features to support your interpretation of metaphases and streamline your karyotyping process.
  • Maintain a continuous log of processing steps and enjoy unrestricted access to the original images.
  • Facilitate smooth transitions between different capture settings, allowing for effortless shifts from brightfield to fluorescence and vice versa.
  • Choose the option for manual image acquisition with one-click capture, automatic contrast enhancement, and the selection of the optimal focus plane.

Color Mode

  • Effortlessly capture images with a single click, utilizing up to 12 color channels.
  • Get correct exposures at the first shot, thanks to automatic integration time.
  • Eliminate the need for time-consuming processing in a dark room.
  • Utilize a monochrome camera for the independent acquisition of single-color channels, automatically merging them to create a color image.
  • Refine and edit specific color channels or even individual areas within the image with selective editing capabilities.
  • View individual color separations and explore various pseudo-color visualizations.
  • Maintain a continuous log of processing steps and enjoy unrestricted access to the original images.
  • Opt for optional upgrades to enable support for color karyotyping, Multicolor FISH (mFISH) and the exclusive Multicolor Chromosome Banding (mBAND) method.
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Description

The Ikaros software integrates an intuitive graphical user interface with a range of potent processing tools, delivering the necessary flexibility in the karyotyping process. Engineered to reduce the number of interactions, Ikaros holds the potential to decrease the time needed for both analysis and result review compared to manual karyotyping.

Ikaros offers tools to assist cytogeneticists in evaluating metaphases prepared using various prevalent chromosome banding methods (such as G-Banding and Q-Banding). It also supports diverse specimen types, including peripheral blood, bone marrow, amniotic fluid, and chorionic villi.

Moreover, Ikaros introduces a color fluorescence mode, displacing traditional photography and eliminating the time-consuming and laborious processing steps typically performed in a darkroom. Color images are produced by sequentially capturing monochrome images of the distinct color components and then automatically combining them to form a cohesive color image. The automated integration time control guarantees accurate exposures from the initial shot, eliminating the need for cumbersome test exposures or guesswork in determining the correct integration time. This not only reduces hands-on time but also extends the lifespan of the specimen. Even faint fluorescent signals against a strong counterstain result in clear and sharp images.

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Neon

Neon is a convenient interface for organizing case and image data. Users configure overview dashboards to summarize cases, processing statuses, and case statistics. Interfaces for data exchange with external databases can be adapted. The fields on case data sheets and reports are customizable to meet specific needs.

Neon serves as general data management software.

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Order Information

While Ikaros can be utilized as a standalone installation, its optimal performance is demonstrated in an environment where multiple workstations collaborate to create an integrated imaging solution. Consequently, Ikaros can be seamlessly integrated into various setups, including karyotyping stations (Ikaros Karyo M), fluorescence imaging stations (Ikaros BASE C and Ikaros Karyo C), data management stations, or review stations (Ikaros Review). With MetaSystems solutions, the scalable multiuser network can be expanded at any time to accommodate growing demands.

When paired with the Metafer software for image acquisition and the detection, classification, and counting of cells, collaborative workspaces can be established, blending performance with high user convenience and robust data security.

Functions that were previously offered as Isis have been merged into the new overall package of the Ikaros software. When updating an existing system, we will of course adapt your licenses so that the range of functions does not change to your disadvantage.

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Legal Note

Metafer 4.3 and Ikaros 6.3 are classified as in vitro diagnostic medical devices (IVD) in the European Union in accordance with In Vitro Diagnostics Regulation (EU) 2017/746 or In Vitro Diagnostic Medical Device Directive 98/79/EC, respectively, and carry the CE label unless otherwise indicated. Use all MetaSystems IVD products only within the scope of their intended purpose.

MetaSystems products are used in many countries worldwide. Depending on the regulations of the respective country or region, some products may not be used for clinical diagnostics.

Some hardware components supplied by other manufacturers are not included in MetaSystems IVD products and are therefore not IVD medical devices.

Please contact us for further information.

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