Home Publications Evolutionary sequence of cytogenetic aberrations during the oncogenesisof plasma cell disorders. Direct evidence at single cell level.
Leuk Res, 35(8), 1114–1116
August, 2011

Evolutionary sequence of cytogenetic aberrations during the oncogenesisof plasma cell disorders. Direct evidence at single cell level.
Zsófia Nagy, Béla Kajtár, Pál Jáksó, Mariann Dávid, Szabolcs Kosztolányi, Judit Hermesz, László Kereskai, László Pajor, Donát Alpár

<p>Bone marrow specimens from 185 patients with plasma cell disorders (PCD) were investigated by fluorescence in situ hybridization (FISH) in order to determine the temporal sequence of cytogenetic aberrations. In 25 cases combined FISH analysis has also been performed at single cell level. Clonal evolution was observed in 16% of cases. The Δ13 was preceded by t(4;14)(p16;q32) and t(14;16)(q32;q23) translocations. Deletion of p53 gene was a secondary aberration compared to Δ13 and t(11;14)(q13;q32) translocation. In 22% of all cases with recurrent IGH translocation, this aberration was presented only in a subset of purified plasma cells questioning its initiating role.</p>

Keywords: Metafer | Ikaros Karyo C (Isis)

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