ASM Microbe 2018–connecting scientists with their science–showcases the best microbial sciences in the world, and provides a one-of-a-kind forum to explore the complete spectrum of microbiology from basic science to translation and application. Eight tracks allow you to narrow in on your scientific niche, and connect with the experts in your field.
Innovative Solutions for Automated Imaging
Since 1986, MetaSystems has been developing and manufacturing systems for automated microscope based imaging. Our close communication and relationships with our customers have been an essential part of the MetaSystems philosophy; the last 30 years have proven that this is a successful strategy. From humble beginnings, MetaSystems has grown into a leading solutions provider while still being connected to our roots as an independent, employee-owned, innovation-driven company.
MetaSystems’ latest innovation, Neon, is a dynamic, modern imaging platform which reliably manages cases, images, and results from single workstation environments to large multi-user, multi-site installations. The Neon imaging platform ensures that all relevant information is accessible whenever needed.
To learn more about our innovative laboratory solutions, we recommend beginning on the application pages. If you are already familiar with our product portfolio, you may proceed directly to the pages covering your product of interest. If you are unable to find what you are looking for, please do not hesitate to contact the MetaSystems partner in your region for assistance.
Are You Looking for Probes?
MetaSystems Probes now has its own website. If you are looking for MetaSystems XCyting DNA Probes, please visit the MetaSystems Probes website.
Toxicology Studies with the Comet Assay and the in-vivo Micronucleus Assay
The genotoxic potential of azidothymidine [...], chosen as a model compound for nucleotide analogs, was comprehensively assessed in vivo for gene mutation, clastogenicity, and DNA breakage endpoints. [...] For the comet assay, liver and stomach were sampled. [...] Coded slides were analyzed by Metafer/Relosys4. A total of 150 comets per slide were measured. [...] For the micronucleus assay in bone marrow, the test methodology was in accordance with requirements of the OECD Guideline 474 [...]. A total of 4000 polychromatic erythrocytes (PCEs) per animal were evaluated for the occurrence of micronuclei and the relative proportion of PCE in relation to normochromatic erythrocytes (NCEs). Blinded slides were analyzed using the Metafer /Relosys 4. Statistical evaluation was performed for the frequency of micronucleated (MN)-PCE. [...] In the comet assay as well as the micronucleus test, AZT caused a considerable dose-dependent increase in DNA damage in all tissues evaluated and was highly cytotoxic to bone marrow and peripheral blood cells. These data are well in line with published results.