Analysis of positive blood cultures for the identification of the most relevant bacteremia-causing bacteria
Bacteremia is one of the most frequent hospital-acquired infections (HAIs). Resultant sepsis and septic shock mandate early intervention because survival rates decrease dramatically by every hour of delayed antibiotic treatment. Initial therapy relies on broad-band antibiotics until the pathogenic microorganisms can be identified. But broad-band antibiotics are often ineffective and contribute to surging bacterial resistance.
Fast pathogen identification, together with information about patient history and resistance incidence, is key for rapid and appropriate adaption of antimicrobial therapy for best patient outcomes – as well as to restrict accelerating antibiotic resistance.
Direct Multiplex Imaging (DMI) enables pathogen identification from mono- and polymicrobial positive blood culture (pBC) within 35 minutes. The assay with 12 genus and species-specific probes with automated image capturing using the Metafer based DMI Scanner enables easy, precise and reproducible identification of over 95% of the sepsis-relevant pathogens.
Gram negative bacteria |
Gram positive bacteria |
|---|---|
| Acinetobacter spp. | Enterococcus faecalis |
| Enterobacteriaceae | Enterococcus faecium |
| Escherichia coli | Staphylococcus aureus |
| Klebsiella pneumoniae | Staphylococcus spp. |
| Proteus mirabilis | Streptococcus pneumoniae |
| Pseudomonas aeruginosa | Streptococcus spp. |
Gram stains, together with the rapid DMI results, provide strong, reliable and cost-effective guidance for antibiotic selection with valuable information about bacteremia causing pathogens. Moreover, DMI has the important advantage over other molecular diagnostics of preserving cell morphology, allowing phenotypic examination and viability assessment.
Due to the labor-saving effects of the straightforward identification protocols, DMI facilitates routine work-up procedures for pBC bottles. Additional tests - such as resistance assays for S. aureus - can be ordered for identified pathogens and contaminated samples can be excluded, thus adding to the cost-efficiency and effectiveness of laboratory operations.
| Name | Order Number | Size |
| Bacteremia DMI Kit | P-7510-010-IG | The kit includes required reagents and consumables for 72 assays |
The yearly MetaSystems Distributor Meeting (DM), brought into life in 2002 as a platform to gather all international partners of MetaSystems and other members of the global MetaSystems family, just ended last week. The DM is being organized in turns by MetaSystems Headquarters, MetaSystems USA (MGI), and MetaSystems Asia. Since MGI is celebrating its 25th anniversary in 2018 they decided to choose a special location: Nassau, The Bahamas!
ECCMID, as the world’s premier Clinical Microbiology & Infectious Diseases event, brings together experts from many fields to present their latest findings, guidelines and experiences to an audience of over 12,000 colleagues. This year, the Programme Committee has developed a multi-faceted program incorporating keynote lectures and oral sessions, as well as interactive workshops, meet-the-expert sessions, and a wide range of symposia.
The focus of the sessions is set to the following topics:
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