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Metafer conveniently automates microscopic image analysis in microbiological diagnostics
Metafer is the imaging and slide scanning solution by MetaSystems for microscopic sample evaluation. This flexible platform is used in thousands of laboratories worldwide for a broad range of clinical applications.
Metafer scans specimen of various sizes and uses different contrasting methods to find target objects. Due to its modularity and flexible architecture Metafer is a highly versatile platform for various microbiological applications, such as automated reading of Gram stains, automated tuberculosis sputum smear microscopy and Direct Multiplex Imaging (DMI) for detection of multiple pathogens directly from patient samples.
Automated imaging saves time, however, equally important is the quality gain because results are obtained and reproducible by applying clearly defined process standards to any application - slide by slide and patient by patient. This way Metafer adds an unbiased degree of result quality.
Complex analysis systems tend to be cumbersome and difficult to understand. Metafer is different: fast access to acquired data, convenient display of results, intelligible user interface and full control of all evaluation parameters guarantee that results are generated exactly the way as needed.
Metafer systems can be fully integrated in existing laboratory information systems (LIS) for import and export of data. Moreover, images can also be written in various file formats to share images for case discussions or to be used for online and web-based trainings.
Each microbiological application is different, requiring flexibility of automation solutions. Metafer’s unique technical design provides a powerful and flexible solution. Classifiers precisely define the imaging and analysis standards needed for the respective application.
Metafer is scalable according to sample volumes. Software and hardware are modular so that the level of automation can be increased as workloads increase. Optional features such as the SlideFeeder x80, automated Bar Code Reader and the automated Immersion Oil Dispenser are easily added upon demand. More information about the high throughput options is available here.
For a list of our reference customers, please click here.
DMI (Direct Multiplex Imaging) is the combination of a novel DNA-based multiplex hybridization technology and automatic imaging. DMI enables fast, specific and reproducible identification of multiple pathogenic microorganisms directly from samples without an additional culture, providing the necessary information for timely
decisions and a targeted antibiotic therapy.
Gram staining is the rapid, easy, and inexpensive method for the assessment of specimen quality, providing early information regarding potential pathogens present in patient samples. Implementation of the Gram Scanner into the laboratory workflow will revolutionize one`s daily routine. The system scans, digitizes and archives – where requested – up to 800 slides in one batch.
Rapid diagnosis of Tuberculosis (TB) is critical for initiation of treatment and infection control. Sputum Smear Microscopy (SSM) of acid fast bacilli is still the most common TB diagnostic test globally because of its simplicity and associated low costs. The Mycobacteria Scanner is a scalable system adjustable to the individual needs of your laboratory and able to scan and analyze 8 to 800 slides in one batch. Auramine or Ziehl-Neelsen stained Mycobacteria are detected and counted automatically using objective and reproducible criteria.
The DMI Bacteremia Kit allows direct identification of the clinically most relevant bacteremia causing pathogens from positive blood culture.
Deep learning techniques can potentially support interpretation of digital Gram images. To match the growing demand for workload reduction and efficiency increase in the review process of Gram stained slides we have integrated deep learning-based object classification using convolutional neural networks (CNN) with our automated scanning platform Metafer to create a unique Gram slide screening environment.
Multiplex hybridization kit for direct identification of the clinically most relevant nosocomial pneumonia causing pathogens from native respiratory patient samples.
Even with escalating expenditures and a dwindling workforce, microbiology laboratories are still expected to meet the demand for prompt and accurate test results at low costs. To meet this challenge, MetaSystems developed the GramScanner, a fully automated walk-away microscope scanning and imaging system. Using the GramScanner, microbiology lab directors can significantly reduce the time their MTs spend at the microscope, increasing the overall efficiency of the lab through more cost-effective use of technicians’ time. This new advanced strategy can even have a direct, positive impact on MT’s health.
MetaSystems, a worldwide leader in microscopic imaging innovation, presented proof of concept results for Deep Learning - based pathogen classification on Gram stain slides.
Thin and thick film evaluations are the gold standard of malaria diagnostic tests. MetaSystems, in collaboration with the University of Milano and the Ospedale Fatebenefratelli-Sacco, Milano, has developed a deep learning algorithm to improve the sensitivity and specificity of malaria microscopy-based evaluations.
